Can legacy Sender and SaF coexist; possible performance issues ?

Can the Sender service coexist with the SaF service on the same node? Similarly, can the Receiver service coexist with the SaF service on the same node?

This question relates to a use case where a legacy driver/collector is used with the Sender/Receiver model, alongside newer collectors (such as the SQL collector) that have been upgraded for version 25 and use SaF.